Mitochondrial Function: OMA1 and OPA1, the Grandmasters of Mitochondrial Health
نویسندگان
چکیده
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منابع مشابه
The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission
Mitochondrial fusion and structure depend on the dynamin-like GTPase OPA1, whose activity is regulated by proteolytic processing. Constitutive OPA1 cleavage by YME1L and OMA1 at two distinct sites leads to the accumulation of both long and short forms of OPA1 and maintains mitochondrial fusion. Stress-induced OPA1 processing by OMA1 converts OPA1 completely into short isoforms, inhibits fusion,...
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عنوان ژورنال:
- Current Biology
دوره 20 شماره
صفحات -
تاریخ انتشار 2010